Metabolism of Drugs. XLVI. Behavior of 2-Naphthyl β-D-Glucofuranosiduronic Acid toward β-Glucuronidase.

• 加藤 敬太郎

• 吉田 和夫

• 塚元 久雄

抄録

2. The kinetics of the hydrolysis of 2-naphthyl β-D-glucofuranosiduronic acid by β-glucuronidase were investigated. The pH optimum of the β-D-glucofuranosiduronic acid is 5.0 in phosphate-citrate buffer at 38°. The reaction velocity is constant with time. The Michaelis-Menten constant is 1.75×10^-2M. The kinetics of the hydrolysis of 2-naphthyl β-D-glucopyranosiduronic acid by the enzyme were also investigated. The pH optimum is 4.7. The Michaelis-Menten constant is 1.3×10^-3M. 3. In view of the above facts, it was concluded that β-D-glucofuranosiduronic acids could be a substrate for β-glucuronidase.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 12 (6), 670-674, 1964

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204174368256
• NII論文ID: 130003765887
• DOI: 10.1248/cpb.12.670
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 14199161
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/12/6/12_6_670/_pdf
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可