The Mechanism of Solubilization of Water Insoluble Substances with Sodium Benzoate Derivatives. I. The Interaction between Water Insoluble Substances and Sodium Benzoate Derivatives in Aqueous Solution

• 上田 省吾

抄録

The interactions between eight water insoluble substances and sodium benzoate derivatives in aqueous solutions were studied spectrophotometrically. It was found that the water insoluble substance used formed one to one molecular complex with sodium benzoate derivative in aqueous system. The formation constants of the complexes were determined at 25° and 60°, with which the enthalpy change ΔH and the entropy change ΔS of complex formation were obtained. As a result, it was suggested that the driving force of the complex formation would be due to charge transfer force or hydrogen bonding.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 14 (1), 22-29, 1966

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679149340416
• NII論文ID: 110003619725
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.14.22
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5920513
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/14/1/14_1_22/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1967071576
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可