Studies on Thiohydroxamic Acids and Their Metal Chelates. III. Syntheses of Some Thiohydroxamic Acid Derivatives and Their Structures

• 永田 耕一

• 水上 聰

抄録

Thiohydroxamic acids react as thiol-form in aqueous solution, and gave S-alkyl and S, O-dialkyl derivatives, dibenzoyl derivatives, and the disulfides (I). Monobenzoyl derivatives were not obtained because of their instability. The structures of these derivatives were confirmed by the investigations of the infrared spectra. It was found that the S-S linkage of I are apt to cleave by alkali so that diacyl derivatives of I are easily rearragned to the corresponding isothiocyanate and 1, 3-dialkyl-2-thiourea. The mechanism of the rearrangement seemed to be analogous to that of the Lossen rearrangement.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 14 (11), 1263-1272, 1966

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204172617472
• NII論文ID: 110003619773
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.14.1263
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/14/11/14_11_1263/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1968034160
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可