Some Pharmacological Factors involved in Formation and Prevention of Stress Ulcer in Rats

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The pharmacological factors which affect the stress ulcer formation were studied in rats Some gastric functions, mainly gastric motility, secretion, blood circulation and protective action of gastric mucosa play the important roles in the ulcer formation induced by the stress which was inflicted by immobilization and immersing in water. Effect of some pharmacedynamic agents on the stress ulcer was examined, and it was found that the secretagogue action is more important than the other pharmacodynamic action tested. Effects of anticholinergics on the gastric functions were also studied, and the close relations between antiulcerous effect and depressive activity of gastric secretion and motility was confirmed. The protective action of gastric mucosa against gastric juice was estimated and the effect of stress and atropine on it was examined. Atropine seemed to have the effect inhibiting the decrease of the protective action of gastric mucosa.

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