The Behavior of 4-Amino-5-carboxy-2-methylpyrimidine in Aqueous Solution

• 平井 瑛三

抄録

The behavior of 4-amino-5-carboxy-2-methylpyrimidine (ACMP) was compared with those of 2-aminoisonicotinic acid (ANA) and 2-aminoisonicotinic acid (AINA) in water. The behaviors of these compounds were investigated spectrophotometrically by comparison with those of the corresponding ethyl ester and 1-methyl betaine. The Edsall-Blanchard equation was used to evaluate the equilibrium constants, K_z between zwitterion from and uncharged from in water. The evaluated K_z values indicated that ACMP, ANA and AINA existed almost completely in the zwitterion form in water, respectively. This result was in good agreement with the spectrophoto-chemical observations.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 14 (8), 861-865, 1966

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204174310912
• NII論文ID: 130003766186
• DOI: 10.1248/cpb.14.861
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5975214
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/14/8/14_8_861/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可