Estimation of the Shelf Life of a Drug in Its Solid State. II. A Proposition for a New Kinetical Equation of Gas-Solid Reactions for Pharmaceutical Solids

• 広田 貞雄

抄録

A new kinetical equation for a gas-solid reaction which is convenient for use in predicting the degradation of a pharmaceutical solid is derived, and a procedure of analyzing accelerated storage data is proposed. The procedure is applied to the air oxidation degradation of ascorbic acid in a mannitol conglomerate. The result of the analysis was consistent with that obtained by Lacey's procedure. With the proposed procedure, operational difficulties met in Lacey's procedure were overcome. The temperature dependence of diffusivity is found to be 56 kcal/mole, with an activation energy for the chemical reaction of 26 kcal/mole. The rate constant for the chemical reaction at 25° is estimated to be 3.3×10^-6 hr^-1, a value which is consistent with the results of Tardif, which were obtained from a different point of view.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 16 (10), 1982-1993, 1968

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679149633024
• NII論文ID: 110003620408
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.16.1982
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5710931
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/16/10/16_10_1982/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1970060289
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可