A Convenient Synthesis of Ribonucleoside 2', 3', -Cyclic Phosphates from Ribonucleosides and Ribonucleotides
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Abstract
Adenosine 5'-phosphate was converted to the 2', 3'-cyclic phosphate by the treatment with dimethylformamide at reflux temperature. The reaction was shown to be proceeded by the initial release of the phosphoryl group as an"activated phosphoric acid"and rephosphorylated to furnish the 2', 3'-cyclic phosphate. In fact a ribonucleoside and phosphoric acid, pyrophosphoric acid, or polyphosphoric acid gives a 2', 3'-cyclic phosphate in a satisfactory yield in refluxing dimethylformamide. This procedure will serve for the preparation of the 2', 3'-cyclic phosphate of synthetic ribonucleoside of a limited quantity.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 18 (11), 2303-2308, 1970
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204169769344
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- NII Article ID
- 110003654593
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DyaE3MXjtF2huw%3D%3D
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- ISSN
- 13475223
- 00092363
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed