Synthetic Antibacterials. II. Synthesis of Pyrido [2, 3-d] pyrimidine Derivatives. (1)

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The condensation of 4-substituted 6-amino-2-methylpyrimidines with diethyl ethoxymethylenemalonate, followed by thermal cyclization in Dowtherm A, yielded the corresponding 4-substituted 2-methyl-5-hydroxypyrido [2, 3-d] pyrimidine-6-carboxylates. These latter compounds served as starting materaials for several transformation reactions.

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