Synthesis of Aminoisoquinolines and Related Compounds. IX. Synthesis of dl-O-Methylcaseadine

• 石渡 三郎

• 板倉 啓壹

抄録

The Mannich reaction of tetrahydroisoquinolines (IVa, b) with 36% formalin in acetic acid gave respectively protoberberines (Va, b) and each compounds were converted to tetramethoxyprotoberberines (Ic, d). Ic was identified by the infrared and nuclear magnetic resonance spectral comparisons with caseadine methyl ether derived from natural caseamine or caseadine. Hydrochloric acid catalyzed condensation of 7, 8-disubstituted tetrahydroisoquinoline (VIII) with 36% formalin gave the same compound (Ic).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 18 (9), 1846-1849, 1970

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679148838272
• NII論文ID: 110003632516
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.18.1846
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/18/9/18_9_1846/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1971087232
• 本文言語コード: en
• データソース種別:
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  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可