Transformation and Excretion of Drugs in Biological Systems. V. Correlation between Renal Excretion and Biotransformation of Sulfadimethoxine

• ARITA TAKAICHI

  Faculty of Pharmaceutical Science, Hokkaido University

• HORI RYOHEI

  Faculty of Pharmaceutical Science, Hokkaido University

• TAKADA MASAHIKO

  Pharmacy, Hokkaido University Hospital

• MISAWA AYAKO

  Pharmacy, Hokkaido University Hospital

抄録

Sulfadimethoxine and its three biotransformed products in man were applied to renal clearance experiments in dogs to elucidate their renal excretion mechanisms.<BR>Clearance ratio of sulfadimethoxine is extremely low compared with each biotransformed product. Of three biotransformed products, clearance ratio of sulfadimethoxine-N1-glucuronide greatly exceeded over the clearance ratio of the other two biotransformed products.<BR>Considerable proximal tubular secretion of sulfadimethoxine-N⁴-acetate was observed. On the contrary, the proximal tubular secretion of sulfadimethoxine-N¹-glucuronide and sulfadimethoxine were insufficient.<BR>Sulfadimethoxine-N¹-glucuronide considerably reduced the affinity to dog plasma protein compared with sulfadimethoxine and sulfadimethoxine-N⁴-acetate.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 19 (5), 930-936, 1971

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150608896
• NII論文ID: 130003766819
• DOI: 10.1248/cpb.19.930
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5557929
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/19/5/19_5_930/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可