Synthesis of N-(Steroid-17-yl)-maleimide

• NAMBARA TOSHIO

  Pharmaceutical Institute, Tohoku University

• SHIBATA TOSHIYUKI

  Pharmaceutical Institute, Tohoku University

• MIMURA MASAAKI

  Pharmaceutical Institute, Tohoku University

• HOSODA HIROSHI

抄録

As the modified cardenolide N-(steroid-17-yl)-maleimide (VII), which is capable of reacting with SH group, has been prepared. Condensation of 17-aminosteroid (IV) with maleic anhydride gave N-(steroid-17-yl)-maleamic acid (V), which on treatment with acetic anhydride was led to VII by intramolecular dehydration (see Chart 2). Formation of isomaleimide (VI), an intermediate leading to VII, is also described.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 19 (5), 954-958, 1971

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150607872
• NII論文ID: 130003766821
• DOI: 10.1248/cpb.19.954
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/19/5/19_5_954/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可