Studies on Aminobutenolide Compounds. I. The Reaction of <I>o</I>-Phthalaldehydic Acid with Amino Compounds

• KUBOTA YUKIO

  The Institute of Physical and Chemical Research

• TATSUNO TAKASHI

  The Institute of Physical and Chemical Research

抄録

An investigation was made on the reaction between o-phthalaldehydic acid (II) and various primary amino compounds.<BR>The reaction with aromatic amines afforded 3-atylaminophthalides (IIIa-j) in good yield. However, the reaction with aliphatic amines did not afford expected III type compounds, but 3, 3'-(N-alkylimino) diphthalides (VIa-d). Similar type compounds (XIa-e) were prepared from ureas, acetamide, and ethyl carbamate.<BR>3-Chlorophthalide (V) reacted with aniline to afford IIIa, but with aliphatic amines, 3-hydroxy-N-alkylphthalimidines (I Xa-d).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 19 (6), 1226-1233, 1971

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150582144
• NII論文ID: 130003766851
• DOI: 10.1248/cpb.19.1226
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/19/6/19_6_1226/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可