Reaction between Carbohydrates and Sulfuric Acid. III. Depolymerization and Sulfation of Chitosan by Sulfuric Acid

• NAGASAWA KINZO

  School of Pharmaceutical Sciences, Kitasato University

• TANOURA NORIKO

  School of Pharmaceutical Sciences, Kitasato University

抄録

Transformation of chitosan in conc. H₂SO₄ was investigated. Neither reaction temperature (0, 10, and 30°) nor time (1-10 hr) affected the degree of sulfation of chitosan, but it was markedly influenced by temperature of the ether used to separate sulfated products. It was proved that depolymerization of chitosan, which had been observed to be extremely stable to conc. H₂SO₄, was influenced by the remaining N-acetyl content in chitosan. As expected, chitosan was greatly depolymerized by treatment with hydrated conc. H₂SO₄ (80 and 90% of sulfuric acid by weight), and sulfated in a lesser extent than that of conc. H₂SO₄.<BR>A hydrolysis constant, K₁ 7.0×10^-2 min^-1, of the acid-labile sulfate in sulfated chitosan indicated a reliable formation of the N-sulfate bound to the amino group in sulfated chitosan.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 20 (1), 157-162, 1972

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204173448960
• NII論文ID: 110003621159
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.20.157
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/20/1/20_1_157/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1972084040
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可