Studies on Fused Hydrazines. II. The Stevens-Type Rearrangement of 2, 3, 5, 10-Tetrahydro-1H-pyrazolo [1, 2-<I>b</I>] phthalazin-s-one Methiodide and Related Compounds

• NAKAMURA AKITADA

  National Institute of Hygienic Sciences

• KAMIYA SHOZO

  National Institute of Hygienic Sciences

抄録

The alkaline decomposition of 2, 3, 5, io-tetrahydro-lH-pyrazolo [1, 2-b] phthalazin-s-one methiodide (VIIa), its methyl derivatives (VIIb-d), and 1, 2, 3, 4, 6, 11-hexahydropyridazo-[1, 2-b] phthalazin-6-one methiodide (XIV) was examined. Compounds VIIa-d afforded 1-methyl-1, 3, 4, iob-tetrahydro-2H-pyrimido [2, 1-a] isoindol-6-ones (VI IIa-d), and XIV afforded 1-methyl-1, 2, 3, 4, 5, 11b-hexahydro-7H-1, 3-diazepino [2, 1-a] isoindol-7-one (XV). In all cases the Stevens-type rearrangement involving lactam nitrogen migration from nitrogen to carbon occurred. Their configuration and conformation were discussed.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 20 (1), 69-75, 1972

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679149965056
• NII論文ID: 130003766938
• DOI: 10.1248/cpb.20.69
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/20/1/20_1_69/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可