Decomposition of Dithiocarbamates. V. The Dissociations of N-Monosubstituted Dithiocarbamic Acids in strongly Acidic and Alkaline Solutions

• TAKAMI FUMITAKA

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• TOKUYAMA KANJI

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• WAKAHARA SHIGERU

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• MAEDA TAKASHI

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

Abstract

The dissociations of five N-monosubstituted dithiocarbamic acids (I) in strongly acidic and alkaline solutions were investigated spectrophotometrically. The existence following equilibrium, _??_(eq. 6) was established. The values of dissociation constants were determined. The Brønsted correlations between pK'_Ior pK'_III and pKa of corresponding amines (pK_N) were found; pK'I or pK'_III 0.48 pK_N+α(α=-9.06 for pK'_I;eq. 7, and α=12.43 for pK'_III;eq.8).

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 21 (2), 329-334, 1973

  The Pharmaceutical Society of Japan

Keywords

• Drug Discovery
• General Chemistry
• General Medicine

Details

• CRID: 1390282679148552960
• NII Article ID: 130003767068
• DOI: 10.1248/cpb.21.329
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/21/2/21_2_329/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed