Syntheses of Ring-substituted Flavonoids and Allied Compounds. XII. Synthesis of (±)-Fukugetin Heptamethyl Ether

• 中沢 浩一

• 和田(今川) 久美子

抄録

3', 4', 5, 7-Tetramethoxyflavon-(8")-ylacetic acid (X), prepared from 2-hydroxy-4, 6-dimethoxyacetophenone (III) in five steps, was condensed with phloroglucinol dimethyl ether (XIV) by means of triphenylphosphine-carbon tetrachloride-triethylamine to give 3, 5-dimethoxyphenyl ester (XV), Fries rearrangement of wbich provided 8-(2"-hydroxy-4", 6"-dimethoxyphenacyl)-3', 4', 5, 7-tetramethoxyflavone (XIII). Condensation of the latter with anisaldehyde in the presence of potassium hydroxide in dimethyl sulfoxidemethanol, followed by cyclization with sulfuric acid afforded the flavonylflavanone derivative (II) identical with natural (±)-fukugetin heptamethyl ether.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 22 (6), 1326-1330, 1974

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679154430848
• NII論文ID: 110003633280
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.22.1326
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/22/6/22_6_1326/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1975025406
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可