"Biopharmaceutical studies on the parenteral preparations". VIII. Effect of some ionic and nonionic surfactants on the intramuscular absorption of isonicothinamide.

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The effects of various surfactants on the intramuscular absorption of water-soluble, micelle-free drug was studied using isonicotinamide as a model compound. 1) Lineality of the clearance curves of the drug was kept even in the presence of either nonionic or ionic surfactants, which indicates that the fundamental mechanism of absorption was unaltered. 2) Absorption inhibitory effects were not specific to nonionic surfactants but were also found in ionic ones in almost equal degrees, and concentration dependency as well. 3) In regard to the homologous serics of polyoxyethylene derivatives of hydrogenated castor oil (HCOs), it has been observed that the smaller the molecular weight and the hydrophlie lipophlie balance are, the greater is the inhibitory effect.

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