Studies on Antiandrogenic Agents. Synthesis of 16β-Ethyl-19-nortestosterone

• 吉岡 晃一

• 後藤 義一

• 馬渕 宏

• 平賀 謙太郎

• 三木 卓一

書誌事項

タイトル別名

• Studies on antiandrogenic agents. Synthesis of 16.BETA.-ethyl-19-nortestosterone.

抄録

The mixture of enol acetates (II and III) of 16-acetyl-estrone-3-methyl ether underwent hydrogenolysis under high pressure (100kg/cm²) of hydrogen in the presence of Raney Ni to form the 16β-ethyl-17β-ol compound (X) in high yield. The mechanism of hydrogenolysis was discussed. This facile and stereoselective introduction of 16β-ethyl and 17β-hydroxy groups was applied to the synthesis of 16β-ethyl-19-nortestosterone (TSAA-291, XIX), which shows strong antiandrogenic activity.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 23 (12), 3203-3207, 1975

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150878976
• NII論文ID: 110003621830
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.23.3203
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 1218454
• Web Site: http://hdl.handle.net/2297/10676
• Web Site: http://hdl.handle.net/2297/11701
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/23/12/23_12_3203/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1976106966
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可