Studies on organic fluorine compounds. XVIII. On the mechanism of the conversion of trifluoromethyl group to amino group on a quinoline ring.

• 小林 義郎

• 熊懐 稜丸

• 榛沢 雄二

• 三村 雅隆

抄録

The mechanism for a novel reaction of a trifluoromethyl group as a leaving group is confirmed. Reaction of 2-(heptafluoro-n-propyl) quinoline with sodium amide gave 2-aminoquinoline, which shows that a perfluoroalkyl group could behave as a leaving group in some SNAr reactions. Tris (trifluoromethyl)-s-triazine gave a 1, 4-ammonia adduct, which shows that the reaction passed through addition-elimination mechanism.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 23 (9), 2044-2047, 1975

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150755072
• NII論文ID: 110003622150
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.23.2044
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/23/9/23_9_2044/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1976076467
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可