13C Nuclear magnetic resonance spectra of antipyrine derivatives and their application to hansch analysis.
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The 13C nuclear magnetic resonance spectra of thirty 4-substituted antipyrine derivatives were examined to obtain the following conclusions : (i) the shielding constants of antipyrine were estimated using the CNDO/2 method ; the signal assignment using the shielding constants was consistent with that based on the experiments ; (ii) the 13C-2H coupling constants of antipyrine were estimated using the CNDO/2 method ; the calculated values are in good agreement with those observed ; (iii) the additive equation on the chemical shifts of the sp3-hybridized carbon was estimated ; the so-called steric effects were observed as a result of this analysis ; and (iv) the Hansch analyses were carried out regarding C-4 of the antipyrine derivatives as the so-called biological active center ; the agreement between the values estimated by the Hansch equation and those observed was fairly good for the analgesic activities.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 24 (1), 61-71, 1976
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679147230848
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- NII論文ID
- 110003634801
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DyaE28Xht1SqsLg%3D
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- ISSN
- 13475223
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可