Formic acid reduction. XXIII. Kinetic studies on the formic acid reduction of carbon-carbon double bond adjacent to carbonyl.

• 鈴木 邦夫

• 府川 秀道

• 奥川 徹

• 関屋 実

抄録

Kinetic manner was introduced into mechanistic studies on the formic acid reduction of carbon-carbon double bond adjacent to carbonyl induced by the formate reagent, TEAF, 5HCO₂H·2NEt₃. Kinetic data obtained by the use of 1, 3-dimethyl-5-benzyli-denebarbituric acid as a representative, the second order kinetics, the large negative entropy of activation, the isotope effect (2.79) and the positive ρ-value (+1.00) of the Hammett equation, suggest one step path, which proceeds by the attack of HCO₂-·HN^⁺Et₃ involving the push-pull mechanism of ring system of a transition state.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 24 (4), 607-612, 1976

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679147263872
• NII論文ID: 110003635021
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.24.607
• COI: 1:CAS:528:DyaE28XkvFenu7k%3D
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/24/4/24_4_607/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1977059362
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可