Reaction of ethyl acetoacetate with isoquinolinium and pyridinium ylides.

• 加藤 鉄三

• 千葉 卓男

• 田中 茂

• 佐々木 俊樹

抄録

Reaction of isoquinolinium bis (ethoxycarbonyl) methylide (I) with ethyl acetoacetate gave ethyl 1-acetyl-2-hydroxypyrrolo [2, 1-α] isoquinoline-3-carboxylate (IV), ethyl 2-methylpyrrolo [2, 1-α] isoquinoline-3-carboxylate (V), diethyl 2-methylpyrrolo [2, 1-α] isoquinoline-1, 3-dicarboxylate (VII), and ethyl 2-ethoxycarbonylmethylpyrrolo [2, 1-α]-isoquinoline-3-carboxylate. Similar reaction of isoquinolinium cyano (ethoxycarbonyl)-methylide (II) with ethyl acetoacetate gave 3-cyano-2-methylpyrrolo [2, 1-α] isoquinoline (IX) and ethyl-3-cyano-2-methylpyrrolo [2, 1-α] isoquinoline-1-carboxylate (X) besides compound VIII. Similarly, reaction of pyridinium bis (ethoxycarbonyl) methylide (XI) with ethyl acetoacetate gave ethyl 1-acetyl-2-hydroxyindolizine-3-carboxylate (XIII).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 25 (10), 2697-2701, 1977

  公益社団法人 日本薬学会

キーワード

• indolizine derivative

詳細情報

• CRID: 1390282679147137920
• NII論文ID: 110003622249
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.25.2697
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/25/10/25_10_2697/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1978106970
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可