Photo-oxygenation of 1H-1,2-diazepine and azepine derivatives: Formation and some reactions of their epidioxides.

• 土屋 隆

• 新井 平八郎

• 長谷川 博司

• 井下 田浩

抄録

The photo-sensitized oxygenation of 1, 2-diazepines (1 and 12) and azepine (17) results in the formation of the corresponding relatively stable epidioxides (2, 13, and 18). The dioxides (2) react with potassium hydroxide to give the epoxy-ketones (10) and with methanol to give the solvent adducts (11), probably via the intermediates (8 and 9). Treatment of 13 with alumina gives the hydroxy-epoxide (15), which is converted to the epoxy-diazepinone (16) by an alkali treatment. However, a similar treatment of 18 with bases gives only N-ethoxycarbonylaniline (19) and does not give any other characterized products.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 25 (10), 2749-2754, 1977

  公益社団法人 日本薬学会

キーワード

• isomerization of epidioxides

詳細情報

• CRID: 1390001204170416512
• NII論文ID: 110003622258
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.25.2749
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/25/10/25_10_2749/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1978107154
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可