Studies on drug nonequivalence. VI. Physico-chemical studies on polymorphism of acetohexamide.

• 黒田 耕司

• 横山 照由

• 梅田 常雄

• 高岸 靖

抄録

Form I, form II, and CHCl₃-II type of acetohexamide are obtained by recrystallization from different solvents. X-ray diffraction patterns, infrared spectra, and differential scanning calorimeter curves of the CHCl₃-II type are identical with those of form II, but CHCl₃-II type contains a chloroform molecule, which cannot be removed by normal drying condition, and CHCl₃-II type seems unsuitable for medical use. The solubility of form II is 1.2 times that of form I.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 26 (8), 2565-2568, 1978

  公益社団法人 日本薬学会

キーワード

• DSC-TG curves

詳細情報

• CRID: 1390282679139378176
• NII論文ID: 110003623330
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.26.2565
• COI: 1:CAS:528:DyaE1cXlvVGquro%3D
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/26/8/26_8_2565/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1979093613
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可