A remarkable elevation of serum calcium concentration induced by ligation of bile duct.

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The change of calcium concentrations in the serum, liver, and bile of rats was investigated after a single oral administration of calcium chloride. The administration of calcium produced a corresponding increase of calcium concentration in the serum and liver, and this increase was dose dependent. A remarkable elevation of calcium content in the bile was caused by the administration of calcium. By the ligation of bile duct, the calcium concentration in the serum was markedly enhanced after the administration of calcium (10 and 50 mg/100g) when compared with that of the sham-operated rats. These results suggest that the excretion of calcium into the bile prevents the elevation of calcium concentration in the serum after the absorption of calcium from the intestine.

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