Conversion of 2,5-diphenyl- and 2,5-dibenzyl-pyrazines to 2,5-diketopiperazines.

• 太田 明廣

• 秋田 安男

• 中根 由美子

抄録

The reactions of 2, 5-diphenyl- (I) and 2, 5-dibenzyl-pyrazine 1-oxides (II) with phosphoryl chloride and acetic anhydride were examined. 2, 5-Dichloro-3, 6-diphenyl- (XI) and 2, 5-dichloro-3, 6-dibenzyl-pyrazines (XIII) were converted to the corresponding 2, 5-diketopiperazines, α-phenylglycine anhydride (XXV) and phenylalanine anhydride (XXVI), respectively. The stereochemistry of the products is discussed. However, attempts to convert 2, 5-dichloro-3, 6-dihydroxymethylpyrazine (XXXIV) to serine anhydride were unsuccessful.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 27 (12), 2980-2987, 1979

  公益社団法人 日本薬学会

キーワード

• phenylalanine anhydride synthesis

詳細情報

• CRID: 1390001204166439552
• NII論文ID: 110003623562
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.27.2980
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/27/12/27_12_2980/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1980110415
• 本文言語コード: en
• データソース種別:
  • JaLC
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  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可