Oxidative cleavage of indoles using copper-pyridine complex.

• 行正 秀文

• 沢井 宏明

• 滝沢 武夫

抄録

Cu₂Cl₂-pyridine-O₂ system oxidize 2-and 3-substituted indole derivatives to form C₂-C₃ double bond cleaved products. By this reaction, 2-substituted indole (6a), 3-substituted indoles (1a-5a) and 2, 3-disubstituted indole (7a) give N-acetylanthranic acid (6b), 2-acylformanilides (1b-5b) and quinolone derivative (7b), respectively. The reaction could represent a mimic of tryptophan 2, 3-dioxygenase reaction, in which tryptophan undergoes oxidative cleavage to give N-formylkynurenin.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 27 (2), 551-553, 1979

  公益社団法人 日本薬学会

キーワード

• 2-acylformanilide

詳細情報

• CRID: 1390001204169771648
• NII論文ID: 110003623647
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.27.551
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/27/2/27_2_551/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1979130844
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可