Antineoplastic activity of platinum complexes of trans-(dl)-1,2-cyclopentanediamine.

• 喜谷 喜徳

• 稲垣 健治

• 八代 有

• 田代 田鶴子

• 塚越 茂

抄録

Dichloro-trans-(dl)-1, 2-cyclopentanediamineplatinum (II) and its derivatives, mixed ligand complexes with oxalato, malonato, or sulfato, were synthesized and tested against Leukemia P-388. All of these complexes have high antineoplastic activity. Among them sulfato-trans-(dl)-1, 2-cyclopentanediamine revealed a very high therapeutic index and is more effective than the corresponding complex of 1, 2-cyclohexanediamine.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 27 (3), 829-830, 1979

  公益社団法人 日本薬学会

キーワード

• mixed ligand complexes

詳細情報

• CRID: 1390001204171802112
• NII論文ID: 110003662260
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.27.829
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 554747
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/27/3/27_3_829/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1980036231
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可