Polynucleotides. LXI. Synthesis and properties of dinucleoside monophosphates containing 8,2'-S-cycloadenosine and 8,2'-S-cycloinosine residues. Sequence dependency of the stability of the stacking conformation.

• 上杉 晴一

• 志田 敏夫

• 池原 森男

抄録

Three dinucleoside monophosphates containing 8, 2'-anhydro-8-thio-9-β-D-arabinofuranosyladenine (A^s) and its hypoxanthine derivative (I^s), A^spI^s, I^spA^s and I^spI^s, were synthesized. Examination of their properties by ultraviolet absorption, circular dichroism and ¹H nuclear magnetic resonance measurements and comparison with the properties of A^spA^s, which has been shown to take a left-handed stacked conformation, showed that all these dimers take a left-handed stacked conformation, and the order of extent of stacking is A^spA^s≈I^spA^s>A^spI^s≈I^spI^s. This sequence dependency of stability of stacking can be explained in terms of the mode of base-base overlap in a left-handed stack. A similar explanation may be applicable to the corresponding sequence dependency of natural dimers with a right-handed stack.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 28 (12), 3621-3631, 1980

  公益社団法人 日本薬学会

キーワード

• UV

詳細情報

• CRID: 1390282679144610816
• NII論文ID: 110003623889
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.28.3621
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/28/12/28_12_3621/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982073410
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
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