Studies on antiatherosclerotic agents. VIII. Synthesis and structure-activity relationship of 4-hydroxymethyl-1(2H)-phthalazinone derivatives.

• 江口 征夫

• 杉本 昭子

• 石川 正幸

抄録

4-Hydroxymethyl-1(2H)-phthalazinone derivatives were synthesized and assayed for their inhibitory effects on platelet aggregation and edematous arterial reaction. Among the tested compounds, 7-ethoxycarbonyl-4-hydroxymethyl-1(2H)-phthalazinone showed the highest potency in these pharmacological tests. The structure-activity relationship of phthalazinone derivatives and related compounds is discussed.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 28 (9), 2763-2769, 1980

  公益社団法人 日本薬学会

キーワード

• relaxing agent for hyperactive arterial endothelial cells

詳細情報

• CRID: 1390282679144002816
• NII論文ID: 110003624095
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.28.2763
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 7460101
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/28/9/28_9_2763/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1981177585
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可