Studies on 1,2,3,4-tetrahydroisoquinolines. III. Syntheses and .BETA.-adrenoceptor activities of methyl derivatives of trimetoquinol.

• 山田 幸一郎

• 武田 幹男

• 伊藤 信夫

• 池沢 一郎

• 清本 昭夫

• 岩隈 建男

抄録

Three methyl derivatives (S-2, S-3, and S-4) of trimetoquinol (TMQ), in which one or both of the ring positions ortho to a phenolic group are substituted by a methyl group, were synthesized and evaluated for bronchodilating activity. They were prepared by NaBH₃CN reduction of the Mannich bases (S-6, S-8, and S-23) via the quaternary salts in a one-pot procedure followed by catalytic reduction on 10% Pd-C. A comparison of the 5-methyl derivative (S-2) with TMQ revealed that the duration of bronchodilating effect of S-2 is considerably longer than that of TMQ on intraduodenal administration.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 29 (10), 2816-2824, 1981

  公益社団法人 日本薬学会

キーワード

• intraduodenal administration

詳細情報

• CRID: 1390282679138943360
• NII論文ID: 130003768853
• DOI: 10.1248/cpb.29.2816
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 6119163
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/29/10/29_10_2816/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可