Synthesis and selective activity of cholinergic agents with rigid skeletons. III.

DOI Web Site PubMed

抄録

Dimethyl quaternary salts of cis- and trans-piperidine-3, 4-diol acetonides (9 and 15) were prepared from readily available intermediates, 1-benzoyl and 1-ethoxycarbonyl derivatives of 1, 2, 5, 6-tetrahydropyridine (4a and 4b). The activity of 9 was examined and the presence of the rigid skeleton was shown to markedly decrease the cholinomimetic effect compared with the partially opened skeleton. The relationship between 9 and known potent muscarinic agents is discussed.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ