Potentiating effects of bradykinin-related substances on bradykinin-induced contraction of guinea pig ileum and hypotension in rats.

• 成瀬 正織

• 山次 貞義

• 周藤 勝一

• 榊原 俊平

• 木村 皓俊

抄録

Bradykinin-related substances were studied in vitro and in vivo for bradykinin-potentiating activity. Of the ten peptides which augmented the contractile response of isolated guinea pig ileum to bradykinin, des-Pro²-bradykinin was the most potent. Its potency was 1.9 times that of potentiator B, a bradykinin potentiating peptide obtained from the venom of Agkistrodon halys blomhoffii. This peptide also potentiated the vasode-pressing activity of bradykinin in rats and inhibited angiotensin converting enzyme. These findings indicate that des-Pro²-bradykinin, like venom peptides, potentiates the activity of bradykinin, possibly by inhibiting angiotensin converting enzyme (kininase II).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 29 (11), 3369-3374, 1981

  公益社団法人 日本薬学会

キーワード

• SQ 14225

詳細情報

• CRID: 1390282679139771008
• NII論文ID: 130003768902
• DOI: 10.1248/cpb.29.3369
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 7337937
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/29/11/29_11_3369/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可