Antitumor activity of 3-nitroso-2-oxazolidones.

• 宮原 美知子

• 宮原 誠

• 神谷 庄造

• 前川 昭彦

抄録

2-Oxazolidones (Ia→f) were not effective against rat ascites hepatoma AH13 or mouse lymphoid leukemia, L1210. However, among 3-nitroso-2-oxazolidones (IIa→f), compounds IIa, IIb, IIc and IId were active against AH13, and compounds IIa, IIb and IIf were active against L1210. Cyclic N-nitrosocarbamates and N-nitrosoureas showed greater antitumor effects than the corresponding acyclic N-nitroso compounds. Since the reaction of compounds IIa→f with 4-(p-nitrobenzyl) pyridine gave a purple color, their antitumor mechanism presumably involves alkylation ; but there was no correlation between the antitumor activities and the color intensities.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 29 (8), 2366-2369, 1981

  公益社団法人 日本薬学会

キーワード

• NBP reagent

詳細情報

• CRID: 1390001204164304640
• NII論文ID: 110003633988
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.29.2366
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 7318043
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/29/8/29_8_2366/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982211795
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可