Effects of oxygenated lanosterol analogs on cholesterol biosynthesis from lanosterol.

• 園田 よし子

• 佐藤 良博

抄録

The effects of oxygenated lanosterol derivatives (1-14) on cholesterol biosynthesis from [24-³H]-lanosterol were tested in 10000×g supernatant (S₁₀) fraction of rat liver homogenate (RLH). Among the derivatives studied, 7-oxo-24, 25-dihydrolanosterol (11) was most active in depressing cholesterol biosynthesis from lanosterol. The inhibitory activities of these derivatives on cholesterol synthesis are discussed in relation to the position and stereochemistry of the oxygen group on the side chain and the sterol nucleus.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 31 (5), 1698-1701, 1983

  公益社団法人 日本薬学会

キーワード

• inhibition of lanosterol demethylation

詳細情報

• CRID: 1390001204163229568
• NII論文ID: 130003769277
• DOI: 10.1248/cpb.31.1698
• COI: 1:CAS:528:DyaL3sXltVWhsL0%3D
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 6616720
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/31/5/31_5_1698/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可