Synthesis and antitumor activity of Pt(II) complexes containing 2,3-diaminopropanol isomers.

• 野路 雅英

• 元山 茂

• 田代 田鶴子

• 喜谷 喜徳

抄録

Halogeno, sulfato, and nitrato Pt (II) complexes of 2, 3-diaminopropanol (pnOH) isomers were synthesized and their antitumor activities against leukemia L1210 were tested. The conformations of their chelate rings were determined to be λ-and δ-gauche forms for R- and S-pnOH, respectively, by ¹³C-nuclear magnetic resonance and circular dichroism spectral analyses. Among the pnOH isomers, Pt (II) complexes containing R-pnOH showed higher antitumor activity than those containing S- or racemic pnOH. It seems that there may be a relationship between the conformations of the chelate rings and antitumor activity in the case of five-membered chelate rings.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 31 (5), 1469-1473, 1983

  公益社団法人 日本薬学会

キーワード

• conformation of chelate ring

詳細情報

• CRID: 1390282679138175616
• NII論文ID: 130003769288
• DOI: 10.1248/cpb.31.1469
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 6616709
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/31/5/31_5_1469/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可