Kinetic study of the degradation of cefotiam dihydrochloride in aqueous solution and of the reaction with aminoglycosides.
抄録
The kinetics of the degradation of cefotiam in aqueous solution was studied at 25°C and an ionic strength of 0.6 over the pH range of 2 to 12. The degradation was a pseudo first order reaction in this pH range. The rate-pH profile showed a characteristic maximum near the isoelectric point of cefotiam (pH 5.8). The optimal pH of an aqueous solution of cefotiam dihydrochloride for stability was calculated to be 8.0. The degradation pathways were shown to involve spontaneous hydrolysis of four ion species and hydroxide ion-catalyzed hydrolysis of the monoanion. Aminoglycosides accelerated the degradation of cefotiam by a pseudo second order reaction. From analysis of the rate-pH profile of the second order rate constants of these aminoglycosides, it appeared that the reaction was substantially a third order reaction with regards to cefotiam, aminoglycoside and hydroxide ion. Therefore, the combined use of cefotiam and aminoglycosides should be avoided at alkaline pH and/or at high concentration.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 31 (6), 2103-2109, 1983
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204164358272
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- NII論文ID
- 130003769353
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- COI
- 1:CAS:528:DyaL3sXlsVKjsb4%3D
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- ISSN
- 13475223
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可