Sparsomycin analogs. III. Synthesis and biological activities of (E)-.BETA.-(6-methyluracil-5-yl)acrylic acid derivatives.

• 金友 昭一

• 永井 外夫

• 大木 一弘

• 長谷 哲子

• 野村 千秋

• 桶崎 英一

抄録

In order to study the structure-activity relationship of sparsomycin, an antitumor antibiotic, 26 sparsomycin analogs (3-5) were synthesized and their antibacterial activities and lytic actions on Ehrlich ascites carcinoma cells were tested. It was found that N-[(E)-β-(6-methyluracil-5-yl) acryloyl]-S-methyl-D-cysteinol (5g) and N-[(E)-β-(6-methyluracil-5-yl) acryloyl]-D-methioninol (5i) showed significant antibacterial activity (minimum inhibitory concentration 25 μg/ml) against Streptococcus pyogenes.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 32 (11), 4625-4631, 1984

  公益社団法人 日本薬学会

キーワード

• sheet method

詳細情報

• CRID: 1390282679140407680
• NII論文ID: 130003769480
• DOI: 10.1248/cpb.32.4625
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 6532561
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/32/11/32_11_4625/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可