Studies on peptides. CLIV. Synthesis of a 36-residue peptide amide corresponding to the entire amino acid sequence of human pancreatic polypeptide.
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- SUGIYAMA NAOKI
- Faculty of Pharmaceutical Sciences, Kyoto University
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- FUJII NOBUTAKA
- Faculty of Pharmaceutical Sciences, Kyoto University
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- FUNAKOSHI SUSUMU
- Faculty of Pharmaceutical Sciences, Kyoto University
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- FUNAKOSHI AKIHIRO
- 3rd Department of Internal Medicine, Kyushu University
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- MIYASAKA KYOKO
- Tokyo Metropolitan Institute of Gerontology
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- AONO MITSURU
- Faculty of Medicine, Kyoto University
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- MORIGA MOTOYUKI
- Faculty of Medicine, Kyoto University
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- INOUE KAZUTOMO
- Faculty of Medicine, Kyoto University
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- KOGIRE MASAFUMI
- Faculty of Medicine, Kyoto University
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- SUMI SHOICHIRO
- Faculty of Medicine, Kyoto University
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- DOI RYUICHIRO
- Faculty of Medicine, Kyoto University
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- TOBE TAKAYOSHI
- Faculty of Medicine, Kyoto University
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- YAJIMA HARUAKI
- Faculty of Pharmaceutical Sciences, Kyoto University
抄録
A 36-residue peptide corresponding to the entire amino acid sequence of human pancreatic polypeptide (hPP) was synthesized by the solution method. A new Asp derivative, Asp (OMen) [Men = menthyl] was employed. Seven fragments served to construct the peptide backbone of hPP and all the protecting groups employed were cleaved by 2 M trimethylsilyl trifluoromethane-sulfonate-diphenylsulfide/trifluoroacetic acid. The synthetic peptide inhibited protein secretion from rat pancreas.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 35 (9), 3585-3596, 1987
公益社団法人 日本薬学会