The effects of new cytochalasins from Phomopsis sp. and the derivatives on cellular structure and actin polymerization.

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Abstract

The effects of ten 10-phenyl-[11]cytochalasans produced by Phomopsis sp. including novel compounds haing 5, 7-or 6, 7-glycol structures and their derivatives, on the cell morphology and actin distribution in C3H-2K cells, as well as on lymphocyte capping and actin polymerization, were examined. The structure-activity relationship reported in the previous papars has been confirmed. The novel glycol type compounds showed little or no activity, suggesting the importance of the perhydroisoindol-1-one nucleus for the manifestation of the cytochalasin actions.

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