Amino Acids and Peptides. XLIV. Synthesis of Stereoisomeric Pentapeptides of Thiol Proteinase Inhibitor.

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Abstract

Stereoisomers of thiol proteinase inhibitor (TPI) were synthesized by a conventional solution method. Among them, iNoc-D-Gln-Val-Ala-Ala-pNA weakly inhibited the aminolytic activity of papain, although iNoc-Gln-Val-Val-Ala-Ala-pNA inhibited papain activity fairly potently. However, the other five D-amino acid-containing peptides did not show any inhibitor effects on papain. The circular dichroism (CD) spectra of the enzyme-peptides mixtures were measured in order to study the relationship between the peptide anilides-papain interaction and the inhibitory activity.

Journal

  • Chemical and Pharmaceutical Bulletin

    Chemical and Pharmaceutical Bulletin 44(8), 1599-1602, 1996

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130003773583
  • Text Lang
    ENG
  • ISSN
    0009-2363
  • Data Source
    J-STAGE 
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