Humoral Antibody Response to the Antigens of Virulent Rhodococcus equi in Foals.

DOI Web Site 2 Citations
  • TAKAI Shinji
    Department of Animal Hygiene, School of Veterinary Medicine and Animal Sciences, Kitasato University
  • KITAJIMA Hisashi
    Department of Animal Hygiene, School of Veterinary Medicine and Animal Sciences, Kitasato University
  • TAMADA Yoshihiro
    Department of Animal Hygiene, School of Veterinary Medicine and Animal Sciences, Kitasato University
  • MATSUKURA Susumu
    Department of Animal Hygiene, School of Veterinary Medicine and Animal Sciences, Kitasato University
  • OHWA Yasuo
    Hidaka Race Horse Breeders Association
  • INUI Takanori
    Hidaka Regional Veterinary Clinical Center
  • KATO Masakatu
    Hidaka Livestock Hygiene Service Center
  • SENO Noboru
    Hidaka Livestock Hygiene Service Center
  • TSUBAKI Shiro
    Department of Animal Hygiene, School of Veterinary Medicine and Animal Sciences, Kitasato University
  • ANZAI Tohru
    Epizootic Research Station, Equine Research Institute, Japan Racing Association
  • KANEMARU Takumi
    Epizootic Research Station, Equine Research Institute, Japan Racing Association
  • KAMADA Masanobu
    Epizootic Research Station, Equine Research Institute, Japan Racing Association

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Other Title
  • 子馬のRhodococcus equi強毒株抗原に対する体液性免疫応答

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Abstract

The antibody response of foals to the antigens of virulent Rhodococcus equi was studied on two horse-breeding farms contaminated with R. equi using Western immunoblotting, and the results were compared with the antibody titers measured by ELISA. Virulent R. equi ATCC 33701 was used as an antigen for these immunoassays. Sera were collected five times from 19 foals on the two farms at regular intervals. ELISA titers o f these sera increased within 60 days after birth, and then gradually decreased to adult levels. Antibody response to the 15- to 17-kDa antigens was detected in accordance with the increase in ELISA titers in every foal. Some of the foals with clinical signs of respiratory tract infection showed a significant increase in ELISA titers. On these farms, virulent R. equi was isolated from their environmental soil. These results suggest that the foals studied were naturally exposed to virulent R. equi, and that humoral response to the 15- to 17-kDa antigens developed in accordance with age during the first 3 months of life

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