書誌事項
- タイトル別名
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- Inhibitory action of nedaplatin on Na+,K+-ATPase activity and its action on human renal proximal tubule epithelial cells.
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抄録
Nedaplatin (NDP), an anticancer platinum complex, is supposed to have stronger action on malignant tumor and less nephrotoxicity than cisplatin. As details of the nephrotoxicity of NDP are not known, we studied the effect of NDP on pig kidney Na+, K+-ATPase activity and human renal proximal tubule epithelial cells (HRPTE cells) . The pig kidney Na+, K+-ATPase activity was inhibited by NDP, and the inhibition depended on the incubation time and the concentration of NDP, and the activity was recovered by sulfides. NDP decreased Na+, K+-ATPase and acid phosphatase activities of HRPTE cells, and the decrease was partially inhibited by addition of 2-mercaptoethanol (2ME) . HRPTE cell death by apoptosis was observed in the presence of NDP, and it was also partially inhibited by 2ME. These results suggest that the inhibition of enzyme activities by NDP may be related to nephrotoxicity, and that some sulfides can recover the activities and may reduce nephrotoxicity.
収録刊行物
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- 歯科薬物療法
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歯科薬物療法 21 (1), 4-12, 2002
日本歯科薬物療法学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204733811968
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- NII論文ID
- 130003840801
- 10016241788
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- NII書誌ID
- AN0023517X
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- ISSN
- 18844928
- 02881012
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可