Suppressive effects of Margarita extract on superoxide generation of human polymorphonuclear leukocytes(PMN).

DOI
  • Luo Xiao Xing
    First Department of Anesthesiology, School of Medicine, Dokkyo University
  • Midorikawa Yukio
    First Department of Anesthesiology, School of Medicine, Dokkyo University
  • Ogata Hiromaru
    First Department of Anesthesiology, School of Medicine, Dokkyo University

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Other Title
  • ヒト白血球の活性酸素に及ぼす真珠抽出液の影響

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Abstract

The effects of Margarita extract on superoxide generation of human PMN were investigatedin vitroby using chemiluminescence method with a 2-methyl-6-phenyl-3, 7-dihydroimidazo [1, 2-a] pyrazin-3-one (CLA) . Superoxide generation stimulated by N-formyl-methionyl-leucyl-phenylalanine (FMLP) or phorbol myristate acetate (PMA) was suppressed with Margarita extract dose dependently with statistic significance at a rate of 67, 41, 34% with FMLP and 42, 33% with PMA in respective dose of 0.5, 1.0, 1.5 mg/2 ml and of 1.0, 1.5 mg/2 ml.<BR>The results suggest that Margarita extract has an anti-oxidative action through suppressing superoxide generation.

Journal

  • Ensho

    Ensho 13 (5), 499-500, 1993

    The Japanese Society of Inflammation and Regeneration

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