腎性上皮小体機能こう進症を有する透析患者における骨組織の臨床病理学的検討

DOI

書誌事項

タイトル別名
  • Clinicopathological study of bone tissues in hemodialysis patients with scondary hyperparathyroidism.

抄録

The desferrioxamine (DFO) test and iliac bone biopsy were performed at the time of TPTX+AT. Amyloid (Am), aluminum (Al), and iron (Fe) deposits were studied in bone tissues by alkaline Congo red, Aluminon, and Berline blue staining, respectively. Various parameters of bone metabolism including serum levels of high sensitivity parathyroid hormone (HS-PTH), Bone Gla protein (OC), aluminum (Al), ferritin (Ft), and alkaline phosphatase (Alp) were determined simultaneously, and their relations with Am, Al, and Fe deposition were evaluated.<br>Al deposits were observed in 5 of 11 patients, and the preoperative DFO test was negative in 1 of these. Fe deposition and Am deposition were seen in 2 patients each. No correlations were observed between Am, Al, or Fe deposition and serum β2-MG, Al, or Ft levels. The serum Alp level was within normal range in 8 of the 11 patients, but the serum OC level was significantly increased in all, suggesting the usefulness of this parameter in the diagnosis of secondary hyperparathyroidism.<br>These results suggest that it is important to examine the deposition of Am, Al and Fe in bone tissues before TPTX+AT.

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詳細情報 詳細情報について

  • CRID
    1390282679653012096
  • NII論文ID
    130003874516
  • DOI
    10.4009/jsdt1985.26.1151
  • ISSN
    18846211
    09115889
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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