慢性腎不全におけるＥＬＩＳＡ法による骨型アルカリフォスファターゼ（ｂｏｎｅ　ＡＬＰ）の測定

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  • Analysis of bone alkaline phosphatase by ELISA methods in renal.

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Bone-type alkaline phosphatase (bone ALP) measured by ELISA, ALP3 measured by electrophoresis on an cellulose-acetate membrane, and serum total alkaline phosphatase were evaluated in patients under renal replacement therapy.<br>Intact PTH, BGP, and intact BGP showed the highest correlations with bone ALP among the ALPs measured by the three different methods (ALP vs intact PTH: r=0.497; ALP3 vs intact PTH: r=0.427; bone ALP vs intact PTH: r=0.667; BGP vs ALP: r=0.548; BGP vs ALP3: r=0.505; BGP vs bone ALP: r=0.750) (intact BGP vs ALP: r=0.421; intact BGP vs ALP3: r=0.414; intact BGP vs bone ALP: r=0.680). In 32 hemodialysis patients with relative hypoparathyroidism (serum intact PTH concentrations below 200pg/ml), total ALP and ALP3 were not significantly correlatied with intact PTH, but bone ALP was (r=0.43, p<0.01).<br>These findings suggest that bone ALP measured by the ELISA method is a useful bone metabolic marker for assessment of bone turnover, particularly in patients with hypoparathyroidism.

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