Imaging Analysis of the Mandibular Morphological Changes in the Acromegaly-like Rat Model

DOI 1 Citations
  • KOJIMA Ikuho
    Division of Oral Diagnosis, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry
  • IIKUBO Masahiro
    Division of Oral Diagnosis, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry
  • KOBAYASHI Akane
    Division of Oral Diagnosis, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry
  • SAKAMOTO Maya
    Division of Oral Diagnosis, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry
  • SASANO Takashi
    Division of Oral Diagnosis, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry

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Other Title
  • 末端肥大症様ラットモデルにおける下顎骨形態変化の画像解析

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Abstract

Purpose: To investigate morphological changes in the mandible using the recently developed acromegaly-like rat model, induced by exogenous administration of insulin-like growth factor I (IGF-I), and to clarify whether the changes are reversible after normalization of the circulating IGF-I level.<br>Material and methods: Human recombinant IGF-I (SOMAZON, Astellas Pharma Inc., Tokyo, Japan) (640μg/day) was subcutaneous infused continuously to 10-week-old male rats for 4 weeks (IGF-I group) (n=6). The control sham-operated animals were injected with saline alone (control group) (n=6). Rats were sacrificed immediately on ending administration (age 14 weeks). Another 12 rats (6 from each group) were housed for an additional 4 weeks after administration ended. Measurement of body weight and blood sampling were done before sacrificing rats (at age 14 and 18 weeks). Then, IGF-I serum level was measured from the sera. After sacrificing the rats, their mandibles were excised. Morphological analysis on the mandible was performed on lateral cephalometric image using soft X-ray equipment (SOFTEX Type CMB, SOFTEX Corp., Tokyo, Japan).<br>Results: Body weights, as well as total IGF-I (human+rat) serum level was markedly higher in the IGF-I group during administration of IGF-I, with a return to the control level after IGF-I administration ceased. Some linear mesurements of the mandible, i. e., Mental foramen (MeF) -Condyle (Cd), MeF-Infradentale (Id), Mandibular foramen (MaF)-Cd, MaF-Id, Cd-Id and Cd-Deepest point of the antegonial notch, significantly increased in the IGF-I group as compared with the control group both during and after IGF-I administration (age 14 and 18 weeks).<br>Conclusion: In our acromegaly-like rat model, specific enlargement of the mandible was found in the length of the condylar process and mandibular body. Such morphological changes were not reversible after normalization of the circulating IGF-I level.

Journal

  • Shika Hoshasen

    Shika Hoshasen 45 (3), 105-109, 2005

    Japanese Society for Oral and Maxillofacial Radiology

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