純粋型および共存型子宮頚部上皮内腺癌の細胞学的検討

DOI 被引用文献3件 参考文献20件

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  • Cytological study of pure adenocarcinoma in situ and coexistence of adenocarcinoma in situ and squamous cell carcinoma of the uterine cervix.

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Thirteen cases of adenocarcinoma in situ (AIS), consisting of 8 pure AIS and 5 with co-existence of AIS and squamous cell carcinoma, were studied cytologically to determine the early stage cervical adenocarcinoma, and the following results were obtained. 1) One false negative case and 7 cases which were diagnosed as suspicious or positive were observed in pure AIS. All cases with the co-existence type were suspicious or positive and 4 out of 5 cases had an abnormality of the squamous epithelium. 2) Cancer was located in the lower side (3 cases), upper side (6 cases), or both sides (4 cases) of the squarno-columnar junction. The cancer depth was<3mm (10 cases, 76.2%), 3-5mm (2 cases) or>5mm (1 case) from the surface of the cervical epithelium. 3) The following characteristics were observed in pure AIS: clear background, crowded sheets of cells and strips of cells in palisading configuration, protrusion of nuclei, oval nuclear shape with less irregularity, and smooth nuclear edge with mild thickness. 4) Nuclear sizes of AIS cells ranged from 11.24×6.69μm for cells in palisading configuration to 9.79×7.52μm for cells in crowded sheets. The long axis of AIS nuclei was significantly longer than that of the nuclei in the follicular and luteinizing phases. The short axis of AIS nuclei was shorter than that of the nuclei in invasive adenocarcinoma. In conclusion, understanding of these cytological features of AIS is important for detecting cervical adenocarcinoma in the early stage.

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