乳癌細胞診のＧｒａｄｅ分類

DOI 被引用文献5件 参考文献17件

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  • Cytologic grade of breast carcinoma.

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Objective: To establish a cytological grading system for breast cancer, 218 cases of Papanicolaou-stained, fine-needle aspirates were retrospectively evaluated in a semiquantitative manner.<BR>Study Design: Fine-needle aspirates from 218 invasive ductal carcinomas were stained using the Papanicolaou method and examined for necrosis, cell size, nuclear/cytoplasmic ratio, nucleoli, chromatin granularity and density, and nuclear pleomorphism. A semiquantitative scoring system was established based on the above features, and correlations between the cytological findings and clinicopathologic variables were examined.<BR>Results: The cytologic grade was positively correlated with the histologic grade and negatively with estrogen-receptor positivity. Moreover, a high cytologic grade was associated with nodal metastasis and proliferative index labeling using MIB-1.<BR>Conclusion: This study showed that our grading system for breast cancer based on fine-needle aspiration cytology can be used for routine diagnoses.

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