A New Synthetic Method for Adenosine 5'-Triphosphate and Other Nucleoside 5'-Triphosphates.

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Reaction of the dicyclohexylguanidinium salt of adenosine 5'-phosphoramidate (I) with tribenzyl pyrophosphate (II) in o-chlorophenol, and reductive debenzylation of the reaction mixture resulted in the formation of adenosine 5'-triphosphate (ATP). The guanidinium salt was reacted with bis-triethylammonium pyrophosphate (V) in a mixture of tricresol and acetonitrile, and ATP was isolated as its barium salt from the reaction mixture by ion-exchange chromatography. The overall yield of ATP from (I) was 43%. Reaction of the dicyclohexylguanidinium phosphoramidates of uridine, cytidine, and desoxyadenosine with (V) also gave uridine, cytidine, and desoxyadenosine 5'-triphosphates in a good yield.

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